Pranav Smart Pharma Intelligence

The Right Drug, Right Dose, Right Chemistry

Pranav Smart Pharma is an AI-powered pharmaceutical intelligence platform that tracks chemical reactions between drugs, recommends medicines based on patient vitals and genetics, monitors food-drug interactions via PranaNutrition, and keeps the liver absolutely safe — delivering golden-grade precision for faster patient recovery.

⚙️ How It Works 🧬 BGI Genomics

15,000+ Drugs Indexed

6 AI Pillars of Safety

CYP450 Genomic Profiling

Zero Preventable ADRs

Pranav Smart Pharma — 6 Intelligence Pillars

⚠️ The Problem

Why India Needs Smart Pharma Intelligence

Adverse Drug Reactions kill thousands every year in India. Most are entirely preventable with the right technology.

💊2.6M+

Adverse drug events in India annually from preventable interactions

🫀11%

Of acute liver failure in India caused by Drug-Induced Liver Injury (DILI)

🧬7-10%

Indians are CYP2D6 poor metabolisers — standard drug doses can be toxic

🥗0%

Food-drug interactions monitored at patient level in current Indian healthcare

📋Fragmented

Patient medication history spread across multiple doctors with no central record

⚙️ End-to-End Pipeline

How Pranav Smart Pharma Works

Every prescription passes through 10 AI-powered safety and optimisation stages — from upload to doctor-approved recommendation.

📸

Upload

Prescription scan or EHR import

🔤

OCR

AI reads drugs & doses

🧪

Identify

Chemical identity mapping

⚠️

Interact

Drug-drug reaction check

🧬

Genomics

CYP450 variant check

🥗

Nutrition

Food-drug cross-check

🫀

Liver

Hepatotoxicity score

❤️

Vitals

Real-time vital context

⭐

Brands

Best generic match

✅

Approve

Doctor review & approval

🧠 Core Intelligence

The 6 AI Intelligence Pillars

Each pillar is an independently deployable microservice that contributes to the overall clinical decision support capability.

⚗️

Drug Chemical Reaction Engine

Maps chemical reactions between 15,000+ drugs — not just binary interactions, but actual pharmacokinetic and pharmacodynamic reaction pathways including CYP enzyme inhibition, chelation, and pH interference.

15K+ Drugs4-Tier SeverityMetabolite Tracking

❤️

Patient Vital-Based Recommender

Consumes real-time vitals from MSR Kiosks and wearables — BP, glucose, eGFR, liver function, SpO2, potassium — to contextualise every drug recommendation to the patient's current physiology.

10 Vital ParametersReal-Time TriggersAuto-Alerts

🎯

Precision Chemical Optimizer

Selects optimal salt form, bioavailability profile, excipient safety, and release mechanism for each patient. Screens for lactose, gluten, and tartrazine sensitivities in formulations.

Salt Form SelectionExcipient SafetyRelease Matching

🛡️

Liver Safety Module

Every drug recommendation passes through a mandatory hepatotoxicity risk assessment. Calculates cumulative liver load, DILI probability, and monitors alcohol-drug-liver interactions via PranaNutrition.

DILI PredictionLiverTox DatabaseCumulative Load

🥗

PranaNutrition Integration

Real-time food-drug interaction intelligence. Monitors grapefruit+statins, dairy+antibiotics, vitamin K+warfarin, tyramine+MAOIs, and caffeine+theophylline — from actual dietary intake data.

72hr Dietary Window8 Critical InteractionsLifestyle Tracking

🧬

BGI Genomics Layer

DNBSEQ whole genome sequencing integration for CYP450 metabolizer phenotyping. Identifies poor/rapid metabolizers for CYP2D6, CYP2C19, CYP3A4 — enabling truly personalised drug selection.

DNBSEQ WGS6 CYP450 GenesCPIC Guidelines

🧬 BGI Genomics Partnership

Pharmacogenomics: DNA-Guided Medication

Pranav Smart Pharma integrates seamlessly with BGI Genomics' DNBSEQ technology to profile the CYP450 enzyme pathways, eliminating "trial-and-error" prescribing for good.

1. DNA Sequencing

Patient saliva/blood sample is processed using BGI's DNBSEQ-T7 ultra-high-throughput sequencer, mapping the full human genome with 99.9% accuracy.

2. Variant Analysis

The GATK/PharmCAT pipeline identifies polymorphisms in key metabolizing genes (CYP2D6, CYP2C19, CYP3A4, SLCO1B1) and assigns a metabolizer phenotype.

3. Precision Dosing

If a patient is a CYP2C19 Poor Metaboliser, Pranav Smart Pharma automatically flags Clopidogrel (Plavix) as ineffective and recommends Prasugrel instead.

🤝 Ecosystem Benefits

Creating Value Across the Healthcare Chain

Pranav Smart Pharma is not just a tool for doctors — it optimizes operations, revenue, and safety across four major stakeholder groups.

💻 Developer Ready

Microservices API Architecture

Built on a robust, event-driven Kafka architecture, providing dedicated microservices for seamless integration with external Hospital Information Systems (HIS).

Kafka Event Streaming

Pranav Smart Pharma uses Apache Kafka to process prescription events asynchronously. When a prescription is ingested, it triggers parallel analysis across the drug interaction, liver safety, and genomics engines — returning a unified risk score in under 2 seconds.

✓ PD-INGEST: Core REST API for OCR / structured prescription ingestion
✓ PD-ANALYSE: GraphQL endpoint for deep chemical property querying
✓ Neo4j Graph DB: Models complex multi-drug metabolic pathway conflicts

// Example API Request: /api/v1/interaction-check
{
  "patient_id": "PRANA-992-BX",
  "vitals": { "egfr": 42.5, "liver_enzymes": "normal" },
  "current_medications": ["Simvastatin 40mg", "Metformin 500mg"],
  "genomic_profile": "CYP3A4_normal",
  "dietary_flags": ["grapefruit_juice"]
}

// API Response: 204ms
{
  "status": "warning_critical",
  "interactions": [
    {
      "drugs": ["Simvastatin", "grapefruit_juice"],
      "mechanism": "CYP3A4 inhibition by furanocoumarins",
      "clinical_effect": "Statin accumulation, myopathy risk",
      "severity": "high",
      "action": "Hold statin or restrict grapefruit intake"
    }
  ]
}